Serum alpha-fetoprotein Values in Dogs with Various Hepaic Diseases.

Maternal Serum Alpha-Fetoprotein Screening

Background: The maternal serum alpha-fetoprotein test (MSAFP) was developed to screen for neural tube defects. Little is known about the adoption of the MSAFP test. This study examines the effect of provider specialty and geographic location and patient insurance status on MSAFP test use in Washington State. Methods: We conducted a retrospective cohort study of MSAFP use in low-risk obstetric p...

Serum alpha-fetoprotein in patients with nonalcoholic fatty liver disease.

We read with interest the Kara et al1, article showing similar serum alpha-fetoprotein (AFP) levels among men with nonalcoholic simple steatosis (SS), steatohepatitis and controls of lower body mass index (BMI), and no discriminating value for NASH1. Following this publication, we performed a post-hoc analysis in a Greek cohort (30 [22 women] patients with biopsy-proven nonalcoholic fatty liver...

Serum alpha-fetoprotein and its lectin reactivity in liver diseases: a review.

Increased serum concentration of alpha-fetoprotein (AFP) can be found in benign and malignant liver diseases, in yolk sac tumors, and in several nonhepatic neoplasms at advanced stage. The frequency and level of elevated serum AFP are highest in hepatocellular carcinoma (HCC) and yolk sac tumors. Most levels of serum AFP in HCC are greater than 500 ng per mL, whereas the serum AFP in most of th...

Alpha-fetoprotein in primary liver cancer and other diseases.

Constitutive elevation of serum alpha-fetoprotein in Fanconi anemia.

The diagnosis of Fanconi anemia (FA) is based on the association of congenital malformations, bone marrow failure syndrome, and hypersensitivity to chromosomal breaks induced by cross-linking agents. In the absence of typical features, the diagnosis is not easy to establish because there is no simple and cost-effective test; thus, investigators must rely on specialized analyses of chromosomal b...